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Insulin-dependent post-transplant diabetes mellitus (PTDM) was reported in 20% of tacrolimus-treated kidney transplant patients without pretransplant history of diabetes mellitus in the Phase III study (See Tables Below).

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Despite improved short-term outcome in renal transplantation, 3 to 5% of allografts per year are still lost; the leading causes are long-term allograft nephropathy and death with a functioning allograft.

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The authors also conclude that additional studies are needed to understand the impact of the magnitude of adherence improvement shown in our study on clinical outcomes prior to broader dissemination of such an adherence program.

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Determine the incidence and severity of acute graft-vs-host disease (GVHD) in patients with hematologic malignancies undergoing donor peripheral blood stem cell transplantation who are receiving sirolimus, tacrolimus, anti-thymocyte globulin, and rituximab as GVHD prophylaxis.

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Due to its potential for nephrotoxicity, consideration should be given to dosing tacrolimus capsules, USP at the lower end of the therapeutic dosing range in patients who have received a liver or heart transplant and have pre-existing renal impairment.

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Two years later, patients body mass index BMI fell from an average of nearly 48 morbidly obese to about 32.

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Methods: To test whether this intra-patient variability is associated with an individual's CYP3A5 genotype, we measured the intrapatient variability in Tac clearance in a cohort of 208 kidney transplant recipients treated with Tac and mycophenolate mofetil.

Using the velocities obtained with SupersomesÒ and the RAF approach, UGT2B7 was predicted to be the major contributor to M3G production in HLM (94 %) and UGT1A3 and UGT1A9 to be minor contributors (4 % and 2 %, respectively).

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