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Insulin-dependent post-transplant diabetes mellitus (PTDM) was reported in 20% of tacrolimus-treated kidney transplant patients without pretransplant history of diabetes mellitus in the Phase III study (See Tables Below).
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Despite improved short-term outcome in renal transplantation, 3 to 5% of allografts per year are still lost; the leading causes are long-term allograft nephropathy and death with a functioning allograft.
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The authors also conclude that additional studies are needed to understand the impact of the magnitude of adherence improvement shown in our study on clinical outcomes prior to broader dissemination of such an adherence program.
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La neumona adquirida en la comunidad, una de las principales enfermedades infecciosas en los pases industrializados, es una importante causa de enfermedad y muerte, segn la informacin de respaldo del estudio que aparece en la edicin en lnea del 29 de mayo de la revista BMJ.
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The discrepancy between these results and our findings may be due to the difference in study design.
Determine the incidence and severity of acute graft-vs-host disease (GVHD) in patients with hematologic malignancies undergoing donor peripheral blood stem cell transplantation who are receiving sirolimus, tacrolimus, anti-thymocyte globulin, and rituximab as GVHD prophylaxis.
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Due to its potential for nephrotoxicity, consideration should be given to dosing tacrolimus capsules, USP at the lower end of the therapeutic dosing range in patients who have received a liver or heart transplant and have pre-existing renal impairment.
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ASW is a KRUK Trustee, and is also their Research Strategy Group Chair and Alumni Ambassador, working with researchers, kidney patients and lay advisors.
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We conclude that, as compared with high-dose oral prednisone alone, treatment of lupus glomerulonephritis with intravenous cyclophosphamide reduces the risk of end-stage renal failure with few serious complications.
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1 The study also observed no significant difference between the 10day treatment group and 5day treatment group in rates of adverse events, AOM recurrence, or antimicrobial resistance.
Careful clinical management with the help of therapeutic drug monitoring is therefore needed for patients receiving drugs which are metabolized by CYP1A2, who stop or start smoking.
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Previously he worked for six years as a Lecturer in Medicine at the former Westminster Hospital before being appointed Consultant Nephrologist and Physician at St Helier Hospital in 1982.
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About half of the ADHD patients were receiving methylphenidate as monotherapy 56.
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Two years later, patients body mass index BMI fell from an average of nearly 48 morbidly obese to about 32.
Five-Year Results of a Randomized Trial Comparing De Novo Sirolimus and Cyclosporine in Renal Transplantation: The Spiesser Study.
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Methods: To test whether this intra-patient variability is associated with an individual's CYP3A5 genotype, we measured the intrapatient variability in Tac clearance in a cohort of 208 kidney transplant recipients treated with Tac and mycophenolate mofetil.
Using the velocities obtained with SupersomesÒ and the RAF approach, UGT2B7 was predicted to be the major contributor to M3G production in HLM (94 %) and UGT1A3 and UGT1A9 to be minor contributors (4 % and 2 %, respectively).
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Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element".
Sirolimus effects on cancer incidence after kidney transplantation: a meta-analysis.
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