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It is prescribed for patients with type 2 diabetes who have not been able to control their glucose with metformin or a sulfonylurea drug.
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When adequate glucose control necessitates treatment therapies in combination with or as an alternative to metformin, use of a DPP-4 inhibitor, GLP-1 receptor agonist, SGLT2 inhibitor, or insulin analog may be preferred over sulfonylureas or traditional insulins if hypoglycemia is a significant concern in a particular patient.
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The findings were included among the 12 Galvus abstracts featured at this week's 19th World Diabetes Congress of the International Diabetes Federation (IDF) in Cape Town, South Africa.
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Edwards CM, Stanley SA, Davis R, Brynes AE, Frost GS, Seal LJ, Ghatei MA, Bloom SR 2001 Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers.
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Kitabchi AE, Temprosa M, Knowler WC, Kahn SE, Fowler SE, Haffner SM, Andres R, Saudek C, Edelstein SL, Arakaki R, Murphy MB, Shamoon H 2005 Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin.
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