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I began to have bruising around insulin injection sites; it looked like I was on anti-coagulants. I am having pain in my joints, and numbness and tingling throughout my body, including my face and tongue. I have a decrease in my ability to taste food. Also, I am bruising from mild injuries with dark purple areas at the site of the bruise.
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Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L et al.
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This medication can harm an unborn baby or cause birth defects.
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The crime is far worse when we discover the drug crims themselves admit statins do not prevent heart attacks or strokes.
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Amy Egan, the FDA's deputy director of safety in the division of metabolism drug products, the new warnings, particularly the one for memory loss, came as the result of anecdotal reports compiled over the past year.
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Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS).
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Eicosanoids derived from arachidonic acid (AA) appear to be involved in the destruction of pancreatic β-cell (insulin producing cells of the pancreas ) population, with the PGE 2 produced from COX enzymatic activity being most relevant and related to COX2 specifically.
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Symptoms such as loss of libido (affected 84% of men), forgetfulness (89%), high appetite (73%), aches and arthalgia (74%), sleeplessness (54%), and laziness (74%) amongst others were noted to be outright abolished despite no changes in placebo.
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As a general antiinflammatory agent (such as its usage in rheumatoid arthritis) it also seems modestly effective.
However, rhabdomyolysis has been reported very rarely with ezetimibe monotherapy and very rarely with the addition of ezetimibe to agents known to be associated with increased risk of rhabdomyolysis, such as fibrates.
Integrating complementary medicine into cardiovascular medicine.
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These measures will help protect the environment.
Good that you stopped taking this DANGEROUS drug that cause MANY side effects.
If gastrointestinal toxicity grade greater than 1 occurs during these first 4 weeks, the subject will be evaluated every 2 weeks until resolution of toxicity to grade less than or equal to 1 and, then, the metformin dose will be increased to the next dose level.
Also, elderly patients in particular are likely to require several medications on a daily basis for managing multiple conditions, and they are also particularly susceptible to difficulties remembering or keeping track of their regimen.
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Zocor which is merely is very safe and the incidence of side effects very low, but some will be affected differently than others.
FDA will review final study report of the SEAS trial to assess additional safety data and provide insight into the risk of cancer.
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Shin YS, Takeda K, Shiraishi Y, Jia Y, Wang M, Jackson L et al.
As shows, a similar theme pervades other statin effects, with statins reported to benefit and worsen proteinuria and to benefit and worsen arrhythmia, cardiac function, and an array of other outcomes.
Thought I was crazy until I was hospitalized for what they thought was a stroke, but it was just reaction to the statin!
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Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial.
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Just take a dosage as soon as it is possible.
Because statins are similar in structure to on a molecular level, they will fit into the enzyme's active site and compete with the native substrate (HMG-CoA).
The reports about memory loss, forgetfulness, and confusion span all statin products and all age groups.
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What should I avoid while taking niacin and simvastatin (Simcor)?
The dosage of simvastatin (once daily in the evening) was 10 mg for the first 8 weeks, 20 mg for the second 8 weeks, and 40 mg thereafter.
In this study, we used existing information within this database to obtain prospective data that allowed us to test the hypothesis that use of statins is associated with a reduced incidence of dementia.
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Simvastatin therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected.
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Atorvastatin 10mg plus ezetimibe 10mg compared with atorvastatin 20mg: Impact on the lipid profile in Japanese patients with abnormal glucose tolerance and coronary artery disease.
The numbers of patients who discontinued the study drug, withdrew consent, or were lost to follow-up were similar in the two groups (Fig.
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Simvastatin significantly decreased plasma levels of total-C, LDL-C, and Apo B (see TABLE 8).
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Since (3 weeks off the statins) I've noticed what I'll call internal jitteryness, and the weak legs continue.
Taking a statin in combination with certain other drugs (gemfibrozil, niacin, and verapamil; check with your doctors for a list of others) can also significantly increase the risk of muscle damage and rhabdomyolysis.
Does simvastatin cause more myotoxicity compared with other statins?
This means that in an unlikely event that any problems occur with your order, we will reship it for free and you will not have to bear any shipping fees or any other additional charges.
Beneficial effects of rosuvastatin alone and in combination with extended-release niacin in patients with a combined hyperlipidemia and low high-density lipoprotein cholesterol levels.
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Food and Drug Administration (FDA) published an update warning consumers and health care providers to curtail the use of.
Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.
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The doctor thought I would require another ablation within a short period of time and therefore would only be on Amiodarone a few months.
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Zocor (or the generic) and Cardizem (or generic).
Oldcarpetcleaner - Oldcynic "we need to be patient patience to benefit their patents" that is the best accurate one liner I heard since "the poor fools have educated themselves beyond their own intelligence" In NZ there is a doco comming up in a couple of weeks "Is your medicine killing you" at last mainstream media might be waking up but I wouldn't hold my breath.
Recognition of potential statin AEs is needed and may be fostered by an improved awareness both of relevant literature and of its limitations.
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FDA concluded that statin-related cognitive effects did not appear to be associated with fixed or progressive dementia, and no association was found for a specific statin, the age of patients, the statin dose, or concomitant medication use.
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Experience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozil, nicotinic acid, cyclosporin, or erythromycin may increase the incidence and the severity of musculoskeletal side effects.
However, promptly talk with him or her about the risks and benefits of your higher dose.
I've been taking these for a year or so, and they seem to be working well enough.
Lungs from OVA-sensitized and OVA-challenged mice receiving either simvastatin or vehicle were excised, and the lung mononuclear cells were purified.
Risk factors for heart disease include family history, high blood pressure, diabetes and older age.
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The drug labeling information on this Web site is the most recent submitted to the and currently in use; it may include, for example, strengthened warnings undergoing FDA review or minor editorial changes.
All patients starting therapy with simvastatin should be advised of the risk of myopathy, including rhabdomyolysis, and told to report promptly any unexplained muscle pain, tenderness or weakness particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after discontinuing simvastatin.
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CPIC extensively reviewed the literature from February 2011 to December 2013 and concluded the dosing recommendations provided in the 2012 CPIC guideline for SLCO1B1 and simvastatin-induced myopathy have not changed.
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A) Atorvastatin; (B) lovastatin; (C) simvastatin.
It makes no sense that the FDA would remove this cautionary warning, as statins are linked to severe liver injury.
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Over the course of the study, treatment with simvastatin led to mean reductions in total-C, LDL-C and TG of 25%, 35%, and 10%, respectively, and a mean increase in HDL-C of 8%.
AHA cholesterol management guideline recommends obtaining liver function tests in adults with symptoms of hepatotoxicity (e.
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Lovastatin and simvastatin are the first HMG CoA reductase inhibitors to receive regulatory agency approval for marketed use.
Egan says these experiences are rare but that those affected often report feeling “fuzzy” or unfocused in their thinking.
No between-group differences in cardiovascular mortality or in the rate of death from any cause were anticipated or observed in IMPROVE-IT, findings that are consistent with those in trials of intensive-dose versus standard-dose statin therapy.
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Use is not currently included in the labeling approved by the US Food and Drug Administration.
Randomized Clinical Trial to Assess the Effect of Statins on Skeletal Muscle Function and Performance: Rationale and Study Design.
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